THE BEST SIDE OF METHADONE PRESCRIPTION EXAMPLE

[sixty one] Like many other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with various potency. Dextromethadone, which can be much less powerful being an opioid, is much more potent at blocking the hERG channel with an IC50 of ~twelve μM. Levomethadone provides a lower affinity, wit